CYCLIZATION OF N-(2,4,6-TRIMETHYLPHENYL)-β-ALANINES
DOI:
https://doi.org/10.1007/264Keywords:
dihydropyrimidinediones, N-substituted beta-alanines, 4-carboxy-2-pyrrolidinones, 4(1H) tetrahydropyridones, condensationAbstract
Reaction of 2,4,6-trimethylaniline with acrylic and itaconic acids gives the corresponding N-substituted β-alanines which can be converted to derivatives of tetrahydropyridone, dihydropyrimidinedione, and 4 carboxy-2-pyrrolidinone. Bromination of the aromatic substituent in the synthesized heterocycles has been carried out.
Authors: V. Mickevicius and A. Patupaite.
English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (7), pp 837-840