SYNTHESIS OF N-AMINOGLYCOSIDES DERIVED FROM ALKALOID CYTISINE, THEIR BIOLOGICAL ACTIVITY AND CRYSTAL STRUCTURE OF N-(β-D-GALACTOPYRANOSYL)CYTISINE
DOI:
https://doi.org/10.1007/2810Keywords:
alkaloid cytisine, N-aminoglycosides, N-(β-D-galactopyranosyl)cytisine, monosaccharides of D-glucose, D-galactose, D-xylose, and L-arabinose, X-ray structural analysis, cytotoxic activityAbstract
Optimal conditions were found for the synthesis of a number of new N‑aminoglycosides of the alkaloid cytisine, using commercially available monosaccharides, namely, D‑glucose, D‑galactose, D‑xylose, and L‑arabinose. X‑ray structural analysis indicated an absolute β‑anomeric configuration of N‑β‑D‑galactopyranosyl)cytisine in the crystalline state. The comparative cytotoxicity of cytisine and some of its N‑aminoglycosides was determined.
How to Cite
Kulakov, I. V.; Nurkenov, O. A.; Turdybekov, D. M.; Mahmutova, A. S.; Ahmetova, S. B.; Sejdahmetova, R. B.; Turdybekov, K. M. Chem. Heterocycl. Compd. 2010, 46, 240. [Khim. Geterotsikl. Soedin. 2010, 300.]
For this article in the English edition see DOI 10.1007/s10593-010-0497-y
