4-HYDROXY-2-QUINOLONES. 44. SYNTHESIS OF 2-R-3-OXOMORPHOLINO[5,6-<i>c</i>]-6-R'-QUINOLIN-5-ONES

Authors

  • С. Г. Таран National Pharmaceutical Academy of Ukraine, Kharkov
  • И. В. Украинец National Pharmaceutical Academy of Ukraine, Kharkov
  • Л. В. Сидоренко National Pharmaceutical Academy of Ukraine, Kharkov
  • О. В. Горохова National Pharmaceutical Academy of Ukraine, Kharkov
  • Нидаль Амин Джарадат National Pharmaceutical Academy of Ukraine, Kharkov

DOI:

https://doi.org/10.1007/292

Keywords:

4-hydroxy-2-quinolones, carbostyryl, morpholinoquinolinone, antituberculosis activity

Abstract

Treatment of 1-R′-2-oxo-4-hydroxyquinolin-3-ylamides of α-halogen-substituted carboxylic acids with sodium methoxide leads to the formation of 2-R-3-oxomorpholino-[5,6-c]-6-R′-quinolin-5-ones. The antituberculosis activity of the compounds synthesized was studied.

Authors: S. G. Taran, I. V. Ukrainets, L. V. Sidorenko, O. V. Gorokhova, and N. A. Jaradat.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (8), pp 944-947

http://link.springer.com/article/10.1007/BF02256978

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Published

2013-02-11

Issue

No. 8 (2000)

Section

Original Papers