4-HYDROXY-2-QUINOLONES. 174. HYDROCHLORIDES OF [(ALKYLAMINO)ALKYL]AMIDES OF 1-ALLYL-4-HYDROXY-6,7-DIMETHOXY-2-OXO-1,2-DIHYDROQUINOLINE-3 CARBOXYLIC ACID – A NEW CLASS OF OPIOID RECEPTOR ANTAGONISTS

Authors

  • И. В. Украинец National University of Pharmacy
  • Л. В. Сидоренко National University of Pharmacy
  • А. А. Давиденко N. I. Pirogov Vinnitsa National Medical University
  • А. К. Ярош Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine

DOI:

https://doi.org/10.1007/2947

Keywords:

4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, opioid receptor antagonists amidation

Abstract

Hydrochlorides salts of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline‑3‑carboxylic acid were synthesized as potential biologically active compounds. Pharmacological testing showed promise for using these compounds to develop new highly efficient opioid receptor antagonists.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Davidenko, A. A.; Yarosh, A. K. Chem. Heterocycl. Compd. 2010, 46, 445. [Khim. Geterotsikl. Soedin. 2010, 560.]

For this article in the English edition see DOI 10.1007/s10593-010-0529-7

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Published

2016-01-13

Issue

No. 4 (2010)

Section

Original Papers