PD-CATALYZED COUPLING REACTION OF 6-HYDROXY- 2-(PROP-2-YN-1-YLSULFANYL)PYRIMIDIN-4(1<i>H</i>)-ONE WITH ARYL IODIDES: EFFICIENT SYNTHESES OF NEW 3-BENZYLTHIAZOLO[3,2-<i>A</i>]PYRIMIDINONES

Authors

  • Ali Keivanloo School of Chemistry, Shahrood University of Technology, P.O. Box 36199-95161, Shahrood
  • Mohammad Bakherad School of Chemistry, Shahrood University of Technology, P.O. Box 36199-95161, Shahrood
  • Taraneh Shahani Islamic Azad University, Saveh Branch, P.O. Box 39187-366, Saveh
  • Amir Hossein Amin School of Chemistry, Shahrood University of Technology, P.O. Box 36199-95161, Shahrood

DOI:

https://doi.org/10.1007/3267

Keywords:

aryl iodide, propargyl bromide, thiazolo[3, 2-a]pyrimidine, thiobarbituric acid, Pd-catalyzed reactions

Abstract

An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[1,3]thiazolo[3,2-a]pyrimidin-
5(7)ones from 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd–Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-a]pyrimidinones in good to high yields.

 

 


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Published

2016-11-07

Issue

Vol. 52 No. 10 (2016)

Section

Original Papers