A DRUG MYSTERY OF HETEROCYCLES: VARIOUS MOLECULES FOR ONE TARGET OR ONE COMPOUND FOR MULTIPLE TARGETS?
DOI:
https://doi.org/10.1007/332Keywords:
ambocarb, 2, 3, 4, 7-tetrahydroindolo[2, 3-c]quinolin-1-ones, inhibitors of MT3/QR2 receptor/enzyme, DYRK1A kinase and L-type calcium channels, multitarget CNS drugsAbstract
Design, development, and biological evaluation of the multitarget series of tetrahydroindolo[2,3-c]quinolinones is based on the "old" drug ambocarb via "deconvolution" approach and reviewed for the potential treatment of neurodegenerative conditions.
Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (1), pp 2-18
http://link.springer.com/article/10.1007/s10593-013-1229-x
