PREPARATION OF BENZIMIDAZOLE <i>N</i>-OXIDES BY A TWO-STEP CONTINUOUS FLOW PROCESS

Authors

  • Fabrizio Politano
  • Elba I. Buján
  • Nicholas E Leadbeater University of Connecticut

DOI:

https://doi.org/10.1007/3534

Keywords:

benzimidazoles, N-oxides, cyclization, flow chemistry, green chemistry, nucleophilic aromatic substitution

Abstract

A continuous flow process for the synthesis of nitrobenzimidazole N-oxides from 2,6-dinitrochlorobenzene and amines or amino acids is reported. The process, performed in a two-step sequence, is faster than previously reported batch processes and avoids some of the isolation and purification steps.

 

Downloads

Published

2016-12-22

Issue

Vol. 52 No. 11 (2016): Non-classical methods of activation in chemistry of heterocyclic compounds

Section

Original Papers