1,5-DIARYLPYRROLES AS POTENT ANTITUBERCULAR AND ANTI-INFLAMMATORY AGENTS

Authors

  • Giulia Venditti Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, Roma I-00185
  • Giovanna Poce Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, Roma I-00185
  • Sara Consalvi Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, Roma I-00185
  • Mariangela Biava Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, Roma I-00185

DOI:

https://doi.org/10.1007/3656

Keywords:

anti-inflammatory agents, antimycobacterial agents, COX-2 selective inhibitors, nitrogen oxide donors, pyrroles, tuberculosis

Abstract

This minireview surveys the work of our research group directed toward finding novel antimycobacterial and anti-inflammatory drugs. Many active compounds were found with a common 1,5-diarylpyrrole skeleton. Some of the synthesized compounds, designed on the basis of structure–activity relationship studies, showed very interesting activities and proved to be effective in vivo, thus providing evidence of their attractiveness for lead optimization.

 

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Published

2017-04-05

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Review Articles