DESIGN, SYNTHESIS, AND CYTOTOXICITY OF PYRIDINE, PYRAZOLE, AND THIAZOLE DERIVATIVES DERIVED FROM <i>N</i>-ALKYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE

Authors

  • M. M. Kamel Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University
  • A. K. El-Ansary Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University
  • Y. R. Milad Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern sciences & Arts (MSA)

DOI:

https://doi.org/10.1007/460

Keywords:

pyridine, tetrahydro-1-benzothiophene, thiazole, thiophene, cytotoxocity

Abstract

The reaction of 4,5,6,7-tetrahydro-1-benzothiophene derivatives with ethyl acetoacetate gave oxobutanamide derivatives. The reactivity of these products towards some chemical reagents was studied to afford new heterocyclic derivatives. The cytotoxicity of the newly synthesized compounds was evaluated against three human tumor cells lines and three normal cell lines. The results showed that some of these compounds exhibit high inhibitory effects towards the three tumor cell lines and the normal cell lines.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 392-403

http://link.springer.com/article/10.1007/s10593-013-1259-4

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Published

2013-04-04

Issue

No. 3 (2013)

Section

Original Papers