SYNTHESIS AND FUNGICIDAL ACTIVITY OF METHYLSULFANYLMETHYL ETHER DERIVATIVES OF LEVOGLUCOSENONE

Authors

  • Булат Т. Шарипов Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054
  • Анна Н. Давыдова Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054
  • Алена С. Рябова Ufa Institute of Biology, Russian Academy of Sciences, 69 Oktyabrya Ave., Ufa 450054
  • Наиля Ф. Галимзянова Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054
  • Фарид А. Валеев Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054

DOI:

https://doi.org/10.1007/4860

Keywords:

γ-butanolides, levoglucosenone, methylthiomethyl ethers, fungicidal activity, Rhizoctonia solani

Abstract

A series of derivatives were synthesized on the basis of levoglucosenone that contained hydroxy groups at the С-4 atom or С-2 and С-4 atoms or a hydroxy and methyl group at the С-4 atom. In addition, 4-hydroxymethylbutanolides were synthesized. Derivatives containing hydroxy groups were obtained as methylsulfanylmethyl ethers. It was established that compounds containing a 6,8-dioxabicyclo[3.2.1]octane ring exhibited fungicidal activity against Rhizoctonia solani. It was shown that the presence of a methylsulfanylmethyl moiety in the ring could increase the fungicidal activity of compounds.

Authors: Bulat T. Sharipov*, Anna N. Davidova, Alena S. Ryabova, Nailya F. Galimzyanova, Farid A. Valeev

Author Biographies

Булат Т. Шарипов, Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054

старший научный сотрудник лаборатории "Фармакофорных циклических систем"

Анна Н. Давыдова, Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054

младший научный сотрудник лаборатории "Фармакофорных циклических систем"

Фарид А. Валеев, Ufa Institute of Chemistry, Russian Academy of Sciences, 71 Oktyabrya Ave., Ufa 450054

заведующий лабораторией "Фармакофорных циклических систем"

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Published

2019-02-13

Issue

Vol. 55 No. 1 (2019)

Section

Original Papers