DIRECT SYNTHESIS OF <i>N</i>-SUBSTITUTED 1,3-OXAZOLIDINES <i>VIA</i> A HETERO-DOMINO PETASIS BORONO-MANNICH REACTION OF 1,2-AMINO ALCOHOLS, FORMALDEHYDE, AND ORGANOBORONIC ACIDS

Authors

  • Yiting Zheng East China University of Science and Technology
  • Lu Sun East China University of Science and Technology
  • Jiayi Wang East China University of Science and Technology
  • Gonghua Song East China University of Science and Technology

DOI:

https://doi.org/10.1007/4898

Keywords:

1, 3-oxazolidines, cyclization, hetero-domino reaction, Petasis borono-Mannich reaction, three-component reaction

Abstract

A simple and convenient approach to the synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids has been reported. The transformation provides an effective and complementary pathway toward 1,3-oxazolidine derivatives.

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Published

2019-07-23

Issue

Vol. 55 No. 7 (2019)

Section

Original Papers