ONE-POT DIASTEREOSELECTIVE SYNTHESIS OF FUNCTIONALIZED 4,5-DIHYDROPYRROLES BY REACTIONS OF ARYLGLYOXALS, β-DICARBONYL COMPOUNDS, AND AROMATIC AMINES

Authors

  • Надежда Н. Колос V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine
  • Сергей А. Карпань V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine
  • Ирина В. Омельченко Scientific-Technological Complex ''Institute of Monocrystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61072, Ukraine
  • Наталья В. Чечина V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine
  • Федор Г. Яременко Scientific-Technological Complex ''Institute of Monocrystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61072, Ukraine

DOI:

https://doi.org/10.1007/5055

Keywords:

acetylacetone, acetoacetic ester, arylglyoxal hydrates, 4, 5-dihydropyrroles, domino reactions.

Abstract

A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities.

Author Biographies

Надежда Н. Колос, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

кафедра органической химии, профессор

Сергей А. Карпань, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

кафедра органической химии, магистр

Ирина В. Омельченко, Scientific-Technological Complex ''Institute of Monocrystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61072, Ukraine

к.х.н.,  ст. научный сотрудник

Наталья В. Чечина, V. N. Karazin Kharkiv National University, 4 Svobody Sq., Kharkiv 61022, Ukraine

кафедра органической химии, аспирант

Федор Г. Яременко, Scientific-Technological Complex ''Institute of Monocrystals", National Academy of Sciences of Ukraine, 60 Nauky Ave., Kharkiv 61072, Ukraine

к.х.н.,  ст. научный сотрудник

Published

2019-09-17

Issue

Section

Original Papers