АЗОТ- И СЕРОСОДЕРЖАЩИЕ ГЕТЕРОЦИКЛЫ. 49. СИНТЕЗ ПРОИЗВОДНЫХ НОВЫХ ГЕТЕРОЦИКЛИЧЕСКИХ СИСТЕМ – 1,2-ДИОКСОЦИКЛОПЕНТА(ГЕКСА)[g]ОКСАЗОЛИДИНО[3,2-f]ПИРИМИДО[4,5-b][1,4]ТИАЗИНА, 1,2-ДИОКСОЦИКЛОПЕНТА(ГЕКСА)[g]ИМИДАЗОЛИДИНО[3,2-f]ПИРИМИДО[4,5-b][1,4]ТИАЗИНА И 1,2-ОКСАЗИНО[5,4-g]ПИРИМИДО[4,5-b][1,4]ТИАЗИНА

T. C. Сафонова; И. E. Мамаева

doi:10.1007/514

HETEROCYCLES CONTAINING NITROGEN AND SULFUR. PART 49. SYNTHESIS OF DERIVATIVES OF NEW HETEROCYCLIC SYSTEMS: 1,2-DIOXOCYCLOPENTA(HEXA)[g]OXAZOLIDINO[3,2-f]PYRIMIDO[4,5-b][1,4]THIAZINE, 1,2-DIOXOCYCLOPENTA(HEXA)[g]IMIDAZOLIDINO[3,2-f]PYRIMIDO[4,5-b][1,4]THIAZINE, AND 1,2-OXAZINO[5,4-g]PYRIMIDINO[4,5-b][1,4]THIAZINE

Authors

T. C. Сафонова Medicinal Substances Chemistry Center, All-Russia Chemical and Pharmaceutical Research Institute, Moscow
И. E. Мамаева Medicinal Substances Chemistry Center, All-Russia Chemical and Pharmaceutical Research Institute, Moscow

DOI:

https://doi.org/10.1007/514

Abstract

The reaction of 4-methoxy-5-amino-6-mercaptopyrimidine with 2-oxo-1-chlorocyclopentyl(hexyl)glyoxalate esters gave derivatives of the previously unknown tetracyclic systems 1,2-dioxocyclopenta(hexa)[g]oxazolidino[3,2-f]pyrimido[4,5-b][1,4]thiazines, which are transformed by ammonium acetate into derivatives of 1,2-dioxocyclopenta(hexa)[g]imidazolidino[3,2-f]pyrimido[4,5-b][1,4]thiazines. Derivatives of the new tricyclic 1-oxazino[5,4-g]pyrimido[4,5-b][1,4]thiazine system were obtained by reaction of 6-carbethoxy-7-acetylpyrimido[4,5-b][1,4]thiazines with hydroxylamine.

Authors: T. S. Safonova and I. E. Mamaeva.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (1), pp 97-100

http://link.springer.com/article/10.1007/BF02251671