SYNTHESIS OF 4-OXO-2-THIOXO-1,2,3,4,5,6-HEXAHYDROSPIRO(BENZO[<i>h</i>]QUINAZOLINE-5,1'-CYCLOHEXANE AND ITS REACTION WITH DIBROMOALKANES

Authors

  • А. И. Маркосян A. L. Mndzhoyan Institute of Fine Organic Chemistry, Armenian National Academy of Sciences
  • P. А. Куроян A. L. Mndzhoyan Institute of Fine Organic Chemistry, Armenian National Academy of Sciences
  • C. В. Диланян A. L. Mndzhoyan Institute of Fine Organic Chemistry, Armenian National Academy of Sciences
  • А. Ш. Оганесян
  • M. C. Алексанян Center for the Investigation of Molecular Structure, Armenian National Academy of Sciences
  • А. А. Карапетян Center for the Investigation of Molecular Structure, Armenian National Academy of Sciences
  • Ю. Т. Стручков Center for the Investigation of Molecular Structure, Armenian National Academy of Sciences

DOI:

https://doi.org/10.1007/515

Abstract

4-(N'-Benzoylthioureido)-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1'-cyclohexane), which was synthesized from 4-amino-3-ethoxycarbonyl-1,2-dihydrospiro(naphthalene-2,1'-cyclohexane) and benzoyl isothiocyanate, cyclized to give 4-oxo-2-thioxo-1,2,3,4,5,6-hexahydrospiro(benzo[h]quinazoline-5,1'-cyclohexane). Reaction of the latter with 1,2-dibromoethane or 1,3-dibromopropane gave products of intramolecular dialkylation at the S and N(3) atoms.

Authors: A. I. Markosyan, R. A. Kuroyan, S. V. Dilanyan, A. Sh. Oganesyan, M. S. Aleksanyan, A. A. Karapetyan, and Yu. T. Struchkov.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (1), pp 101-105

http://link.springer.com/article/10.1007/BF02251672

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Published

2013-04-22

Issue

No. 1 (1999)

Section

Original Papers