A FOUR-COMPONENT BIGINELLI REACTION: NEW OPPORTUNITIES FOR THE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES

Authors

  • Vladimir L. Gein Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990
  • Tatiana M. Zamaraeva Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990
  • Ekaterina V. Gorgopina Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990
  • Maksim V. Dmitriev Perm State University, 15 Bukireva St., Perm 614990

DOI:

https://doi.org/10.1007/5321

Keywords:

aromatic aldehyde, hexahydropyrimidine, methyl aroylpyruvate, thiourea, urea, Biginelli reaction, X-ray structural analysis

Abstract

Methyl 5-aroyl-6-aryl-4-methoxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates were synthesized by four-component Biginelli reaction of methyl aroylpyruvate, aromatic aldehyde, urea (thiourea), and MeOH in the presence of NaHSO4. The products were obtained in moderate to high yields.

Author Biographies

Vladimir L. Gein, Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990

заведующий кафедрой общей и органической химии ФГБОУ ВО ПГФА Минздрава России

Tatiana M. Zamaraeva, Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990

доцент кафедры общей и органической химии ФГБОУ ВО ПГФА Минздрава России

Ekaterina V. Gorgopina, Perm State Pharmaceutical Academy, 2 Polevaya St., Perm 614990

аспирант кафедры общей и органической химии ФГБОУ ВО ПГФА Минздрава России

Maksim V. Dmitriev, Perm State University, 15 Bukireva St., Perm 614990

доцент кафедры органической химии ПГНИУ

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Published

2020-04-01

Issue

Vol. 56 No. 3 (2020)

Section

Original Papers