FACILE SYNTHESIS OF ISONIAZID DERIVATIVES – 1-[2-(3-ARYL(HETARYL)-1-PHENYL-1<i>H</i>-PYRAZOL-4-YL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOL-3(2<i>H</i>)-YL]ETHANONES
DOI:
https://doi.org/10.1007/5357Keywords:
acylhydrazones, coumarins, hetaryloxadiazoles, isoniazid, ultrasonication.Abstract
A facile and efficient ultrasound-aided approach has afforded cyclization of isoniazid hydrazones into 2,5-bishetaryloxadiazolines at ambient temperature. Acetic anhydride helped in intramolecular oxidative cyclization along with N-acylation of oxadiazoline. The synthesized 1-[2-(1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethanones were isolated in good yields, spectral data supported the proposed structures.
Downloads
Published
2020-05-28
Issue
Section
Short Communications