A SIMPLE SYNTHESIS OF 2-{2-[(ARYLMETHYLIDENE)AMINO]-INDAZOL-3-YL}MALONATE ESTERS
DOI:
https://doi.org/10.1007/5468Keywords:
aldehydes, alkenes, aziridines, indazoles, organic azides.Abstract
A method was developed for the synthesis of dimethyl {2-[(arylmethylidene)amino]-2H-indazol-3-yl}malonates on the basis of a Knoevenagel condensation between 2-azidobenzaldehyde and dimethyl malonate, followed by treatment of the obtained adduct with aromaticaldehydes in the presence of polymer-supported triphenylphosphine. It was shown that the interaction of the synthesized Schiff bases with Corey ylide provided a route for the synthesis of 2-(aziridin-1-yl)indazoles.