RING-CHAIN TAUTOMERISM OF 2-ARYL-6-OXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID SODIUM SALTS

Authors

  • А. Ю. Ершов Institute of Macromolecular Compounds, Russian Academy of Sciences
  • Д. Г. Наследов Institute of Macromolecular Compounds, Russian Academy of Sciences
  • К. В. Насонова Institute of Macromolecular Compounds, Russian Academy of Sciences
  • К. В. Сезявина Institute of Macromolecular Compounds, Russian Academy of Sciences
  • Т. В. Сусарова Institute of Macromolecular Compounds, Russian Academy of Sciences
  • И. В. Лагода Research Test Medical and Biological Protection Center, State Research Test Institute of Military Medicine, Ministry of Defence of the Russian Federation
  • В. В. Шаманин Institute of Macromolecular Compounds, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/557

Keywords:

2-aryl-6-oxohexahydropyrimidine-4-carboxylic acids, ring-chain tautomerism

Abstract

It was shown by 1H and 13C NMR spectroscopy that the 2-aryl-6‑oxohexahydropyrimidine-4-carboxylic acid sodium salts existed in D2O solution as a tautomeric mixture of cyclic and linear forms. The cyclic form consisted of two (2RS,4S)-stereoisomers, differing in the aryl substituent configuration at the pyrimidine ring C-2 atom.

Authors: A. Yu. Ershov, D. G. Nasledov, K. V. Nasonova, K. V. Sezyavina, T. V.  Susarova, I. V. Lagoda, and V. V. Shamanin

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (4), pp 598-603

http://link.springer.com/article/10.1007/s10593-013-1287-0

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Published

2013-05-02

Issue

No. 4 (2013)

Section

Original Papers