SYNTHESIS OF 5-AMINO-1<i>H</i>-PYRAZOLO[4,3-<i>b</i>]PYRIDINE DERIVATIVES AND ANNULATION OF IMIDAZOLE AND PYRIMIDINE RINGS THERETO
Authors
Георгий Г. Яковенко
National University ''Kyiv-Mohyla Academy'',
2 Hrygorija Skorovody St., Kyiv 04655, Ukraine
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02660, Ukraine
Олег А. Лукьянов
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02660, Ukraine
Марта С. Ягодкина-Яковенко
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02660, Ukraine
Андрей В. Больбут
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv 02660, Ukraine
Enamine Ltd.,
78 Chervonotkatska St., Kyiv 02094, Ukraine
Михаил В. Вовк
Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02660, Ukraine
1-Alkyl-N-Boc-5-formylpyrazol-4-amines react with malononitrile and cyanoacetamide to form 5-amino-1H-pyrazolo[4,3-b]pyridine nitriles and amides, respectively. Cyclocondensation of the obtained derivatives with chloroacetaldehyde, bromotrifluoroacetone, or ethyl bromopyruvate leads to the formation of imidazo[1,2-a]pyrazolo[3,4-e]pyridines or to pyrazolo[3',4',5,6]pyrido[2,3-d]pyrimidine derivatives in cyclocondensation with orthoesters, ethyl oxalyl chloride, or carbonyldiimidazole.
Author Biography
Михаил В. Вовк, Institute of Organic Chemistry, National Academy of Sciences of Ukraine,
5 Murmanska St., Kyiv 02660, Ukraine
