INDOLE DERIVATIVES OF FUSIDANE TRITERPENOIDS: SYNTHESIS AND THE ANTIBACTERIAL ACTIVITY

Authors

  • Елена Е. Салимова Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 141 Oktyabrya Ave., Ufa 450075, Russia
  • Айгуль А. Магафурова Bashkir State University, 32 Zaki Validi St., Ufa 450074, Russia
  • Елена В. Третьякова Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 141 Oktyabrya Ave., Ufa 450075, Russia
  • Ольга С. Куковинец Bashkir State University, 32 Zaki Validi St., Ufa 450074, Russia
  • Людмила В. Парфенова Institute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, 141 Oktyabrya Ave., Ufa 450075, Russia

DOI:

https://doi.org/10.1007/5597

Keywords:

indoles, fusidic acid, antibacterial activity, Fischer reaction.

Abstract

New indole derivatives of fusidic acid were synthesized by using the Fischer reaction. The obtained compounds were screened in vitro for antibacterial activity and were found to inhibit the growth of Staphylococcus aureus (MRSA, strain ATCC 43300) at concentrations comparable to fusidic acid. The obtained indole derivatives of fusidic acid were also characterized by relatively low cytotoxicity and minimal hemolytic effect at the highest concentration that was tested (32 μg/ml).

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Published

2020-07-10

Issue

Vol. 56 No. 6 (2020): Heterocyclic сompounds in medicinal chemistry

Section

Short Communications