SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 4<i>H</i>-3,1-BENZOTHIAZIN-4-ONES

Authors

  • Lan Phuong Vu Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121
  • Michael Gütschow Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121

DOI:

https://doi.org/10.1007/5741

Keywords:

4H-3, 1-benzothiazin-4-ones, enzyme inhibitors, receptors antagonists, ring closure

Abstract

4H-3,1-Benzothiazin-4-ones are accessible by various preparative routes mostly starting from anthranilic acid derivatives. These facile synthetic entries allow for the introduction of diverse substituents at positions 2 and 5–8. In this review, representative methods to generate 4H-3,1-benzothiazin-4-ones and the biological activities of the resulting products are highlighted.

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Published

2020-07-10

Issue

Vol. 56 No. 6 (2020): Heterocyclic сompounds in medicinal chemistry

Section

Review Articles