RECYCLIZATION OF <i>N</i>-ARYLITACONIMIDES WITH CARBOXIMIDAMIDES – A NOVEL EFFICIENT METHOD FOR THE SYNTHESIS OF 2-(2-AMINO-6-OXO-1,4,5,6-TETRAHYDROPYRIMIDIN-5-YL)ACETANILIDES

Authors

  • Никита М. Сотников Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Юрий А. Ковыгин Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Дмитрий Ю. Вандышев Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Ирина В. Леденёва Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Евгения А. Кошелева Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Олег А. Козадёров Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia
  • Хидмет С. Шихалиев Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

DOI:

https://doi.org/10.1007/5771

Keywords:

carboximidamides, dihydropyrimidines, itaconimides, hybrid molecules, recyclization.

Abstract

A convenient method for the preparation of 2-(2-amino-6-oxo-1,4,5,6-tetrahydropyrimidin-5-yl)acetanilides based on the reaction of N-arylitaconimides with various carboximidamides has been proposed. In the course of the transformation, a cascade reaction occurs encompassing the aza-Michael addition of carboximidamides to N-arylitaconimides and the subsequent recyclization of intermediates to dihydropyrimidine acetanilides.

Author Biographies

Никита М. Сотников, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Магистрант кафедры органической химии

Юрий А. Ковыгин, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Доцент кафедры органической химии

Дмитрий Ю. Вандышев, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Доцент кафедры органической химии

Ирина В. Леденёва, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Старший научный сотрудник кафедры органической химии.

Евгения А. Кошелева, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Научный сотрудник кафедры органической химии

Олег А. Козадёров, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Доцент кафедры физической химии.

Хидмет С. Шихалиев, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia

Профессор, зав. кафедрой органической химии

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Published

2021-02-22

Issue

Vol. 57 No. 2 (2021)

Section

Original Papers