SYNTHESIS OF 6-ALKYLTHIO-5-CARBAMOYL-3-CYANO-4-PHENYL-3,4-DIHYDROPYRIDIN-2(1H)-ONES

Abstract

Condensation of ethyl benzylidenecyanoacetate with thiocarbamoylacetamide in the presence of an equimolar amount of piperidine produces piperidinium 5-carbamoyl-3-cyano-2-oxo-4-phenyl-3,4-dihydropyridine-6(1H)-thiolate, which is then used in synthesis of the corresponding 6-alkylthiosubstituted 3,4-dihydropyridin-2(1H)-ones.

Authors: A. Krauze and G. Duburs.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (4), pp 446-449

http://link.springer.com/article/10.1007/BF02319332