SYNTHESIS OF MESITYL-SUBSTITUTED 1,3,4-OXADIAZOLES FROM MESITOTRICHLORIDE AND AROMATIC AND HETEROAROMATIC ACID HYDRAZIDES

Abstract

At interaction of 2,4,6-trimethylbenzotrichloride with aromatic (heteroaromatic) acid hydrazides in a mixture of 2,6-lutidine and tert-butanol the processes of alcoholysis and reductive condensation are suppressed. The corresponding 2-aryl- or 2-hetaryl-5-mesityl-1,3,4-oxadiazoles are obtained in high yields. The PMR, IR, and mass spectra of the products are studied.

Authors: L. I. Belen'kii, S. I. Luiksaar, and M. M. Krayushkin.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (4), pp 492-498

http://link.springer.com/article/10.1007/BF02319340