METHODS OF SYNTHESIS AND ANTIVIRAL ACTIVITY OF NEW 4-ALKYL-3-NITRO-1,4-DIHYDROAZOLO[5,1-<i>с</i>][1,2,4]TRIAZIN-4-OLS

Authors

  • Роман А. Дрокин Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Дмитрий В. Тюфяков Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Егор К. Воинков Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia
  • Павел А. Слепухин Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Евгений Н. Уломский Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia
  • Яна Л. Есаулкова Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Александрина С. Волобуева Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Кристина С. Ланцева Saint Petersburg State University, 7/9 University Embankment, Saint Petersburg 199034, Russia
  • Мария А. Мисюрина Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Владимир В. Зарубаев Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, 14 Mira St., Saint Petersburg 197101, Russia
  • Владимир Л. Русинов Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg 620002, Russia Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg 620108, Russia

DOI:

https://doi.org/10.1007/6031

Keywords:

3-nitroazolo[5, 1-с][1, 2, 4]triazines, α-nitro ketones, triazines, antiviral activity, Coxsackie B3 virus, influenza virus.

Abstract

An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

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Published

2021-05-05

Issue

Vol. 57 No. 4 (2021): Heterocycles Against Viruses

Section

Original Papers