CYCLIC ISOTHIOUREA IN DRUG DESIGN

Authors

  • Evgeniya V. Nurieva Lomonosov Moscow State University, Department of Chemistry, 1, Build. 3 Leninskie Gory, Moscow 119991
  • Alexander A. Alexeev Lomonosov Moscow State University, Department of Chemistry, 1, Build. 3 Leninskie Gory, Moscow 119991 Institute of Physiologically Active Compounds, 1 Severny Proezd, Chernogolovka 142432, Moscow Region
  • Olga N. Zefirova Lomonosov Moscow State University, Department of Chemistry, 1, Build. 3 Leninskie Gory, Moscow 119991 Institute of Physiologically Active Compounds, 1 Severny Proezd, Chernogolovka 142432, Moscow Region

DOI:

https://doi.org/10.1007/6289

Keywords:

cyclic isothiourea, thiazole, bioisostere, conformational restriction, drug design

Abstract

The present minireview concerns the application of cyclic isothiourea moiety (with endocyclic sulfur atom) in drug design and includes the examples of bioisosteric replacement, conformational restriction, etc. The synthetic procedures leading to the target structures of cyclic isothioureas and their bicyclic derivatives are also discussed. The review gives multiple useful examples for the chemists searching novel heterocyclic compounds with neuroprotective, antihypotensive, antiproliferative, antiobestic, and analgetic properties.

Author Biography

Evgeniya V. Nurieva, Lomonosov Moscow State University, Department of Chemistry, 1, Build. 3 Leninskie Gory, Moscow 119991

Department of Chemistry

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Published

2021-09-22

Issue

Vol. 57 No. 9 (2021)

Section

Review Articles