MICROWAVE-ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME PYRAZOL-1-YLQUINOXALIN-2(1H)-ONE DERIVATIVES

Authors

  • Olayinka O. Ajani Chemistry Department, College of Science and Technology, Covenant University, Canaanland, Km 10, Idiroko Road, P.M.B. 1023, Ota, Ogun State
  • Craig A. Obafemi Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-ife, Osun State
  • Chinwe O. Ikpo Chemistry Department, College of Science and Technology, Covenant University, Canaanland, Km 10, Idiroko Road, P.M.B. 1023, Ota, Ogun State
  • Kehinde O. Ogunniran Chemistry Department, College of Science and Technology, Covenant University, Canaanland, Km 10, Idiroko Road, P.M.B. 1023, Ota, Ogun State
  • Obinna C. Nwinyi Department of Biological Sciences, College of Science and Technology, Covenant University, Canaanland, Km 10, Idiroko Road, P.M.B. 1023, Ota, Ogun State

DOI:

https://doi.org/10.1007/6450

Keywords:

3-hydrazinoquinoxalin-2(1H)-one, imines, gram-positive bacteria

Abstract

3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di-
hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active at MIC value of 7.8 µg/ml.

How to Cite
Ajani, Olayinka O.; Obafemia, Craig  A.; Ikpo, Chinwe O.;
Ogunniran, Kehinde O.; Nwinyi, Obinna C. Chem. Heterocycl. Compd. 2009, 45, 1370. [Khim. Geterotsikl. Soedin. 2009, 1703.]

For this article in the English edition see DOI 10.1007/s10593-010-0435-z

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Published

2021-10-07

Issue

No. 11 (2009)

Section

Original Papers