REACTION OF 2-ALKYLTHIO-6-AMINOPYRIMIDIN-4(3H)-ONES WITH ETHYL BROMOPYRUVATE. SYNTHESIS OF FURO[2,3-<i>d</i>]PYRIMIDINE AND FURO[3,2-<i>e</i>]IMIDAZO[1,2-<i>c</i>]PYRIMIDINE CARBOXYLATES

Authors

  • V. Masevicius Vilnius University Department of Organic Chemistry, Vilnius LT-03225
  • G. Petraityte Vilnius University Department of Organic Chemistry, Vilnius LT-03225
  • S. Tumkevicius Vilnius University Department of Organic Chemistry, Vilnius LT-03225

DOI:

https://doi.org/10.1007/6788

Keywords:

furo[3, 2-e]imidazo[1, 2-c]pyrimidines, furo[2, 3-d]pyrimidines, pyrimidin-4(3H)-ones, cyclization

Abstract

Reaction of 2-alkylthio-6-aminopyrimidin-4(3H)-ones with ethyl bromopyruvate to give ethyl 2-alkylthio-4-aminofuro[2,3-d]pyrimidine-5-carboxylates has been shown to proceed under neutral or acidic conditions. The obtained furo[2,3-d]pyrimidines underwent further cyclocondensation reaction with ethyl  bromopyruvate to afford diethyl 5-alkylthiofuro[3,2-e]imidazo[1,2-c]pyrimidine-2,9-dicarboxylates.

How to Cite
Masevicius,  V.; Petraityte,  G.; Tumkevicius, S.  Chem. Heterocycl. Compd. 2009, 45, 357. [Khim. Geterotsikl. Soedin. 2009, 440.]

For this article in the English edition see DOI 10.1007/s10593-009-0264-0

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Published

2022-05-11

Issue

No. 3 (2009)

Section

Original Papers