4-HYDROXY-2-QUINOLONES. 148. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 1-HYDROXY-3-OXO-6,7-DIHYDRO-3H,5H-PYRIDO[3,2,1-<i>ij</i>]QUINOLINE-2-CARBOXYLIC ACID N-R-AMIDES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • А. А. Ткач National University of Pharmacy, Kharkiv 61002
  • Л. А. Гриневич National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/7154

Keywords:

hetarylamides, 4-hydroxy-2-oxoquinoline-3-carboxylic acids, amidation, antitubercular activity, X-ray structural analysis

Abstract

An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3  and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.

How to Cite
Ukrainets, I. V.; Tkach, A. A.; Grinevich, L. A.  Chem. Heterocycl. Compd. 2008, 44, 956. [Khim. Geterotsikl. Soedin. 2008, 1189.]

For this article in the English edition see DOI 10.1007/s10593-008-0139-9


Downloads

Published

2022-10-24

Issue

No. 8 (2008)

Section

Original Papers