SYNTHESIS OF NEW PYRROLO[3,4-<i>c</i>]ISOXAZOLE, PYRROLO[2,3-<i>d</i>][1,2,3]TRIAZOLE, TRIAZOLO[4,5-<i>c</i>]PYRIDAZINE, AND DIPYRROLO[3,2-<i>b</i>:3',4'-<i>d</i>]PYRAN DERIVATIVES

Authors

  • F. A. Amer Chemistry Department, Faculty of Science, Mansoura University, Mansoura
  • M. Hammouda Chemistry Department, Faculty of Science, Mansoura University, Mansoura
  • A.-A. S. El-Ahl Chemistry Department, Faculty of Science, Mansoura University, Mansoura
  • B. F. Abdel-Wahab Applied Chemistry Department, National Research Center, Dokki, Giza

DOI:

https://doi.org/10.1007/7317

Keywords:

oxime, β-oxonitriles, pyrrolidin-3-ones, aldol condensation

Abstract

New pyrrolo[3,4-c]isoxazole  derivatives were synthesized from  the key  intermediates 4-cyanopyrrolidin-3-ones in two steps. Pyrrolo[2,3-d][1,2,3]triazoles and  triazolo[4,5-c]pyri-dazine were obtained from 2-arylhydrazono-4-cyano–1-(4'-methoxyphenyl)-3-oxopyrrolidines by refluxing with phenylhydrazine in either ethanol or glacial acetic acid. Aldol self-condensation of 1-aryl-4-cyanopyrrolidin-3-ones afforded dipyrrolo[3,2-b:3',4'-d]pyran derivatives.

How to Cite
Amer, F. A.; Hammouda, M.; El-Ahl, A.-A. S.; Abdel-Wahab, B. F.  Chem. Heterocycl. Compd. 2007, 43, 1559. [Khim. Geterotsikl. Soedin. 2007, 1841.]

For this article in the English edition see DOI 10.1007/s10593-007-0241-4

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Published

2023-01-16

Issue

No. 12 (2007)

Section

Original Papers