5-ARYLMETHYLIDENE-2-IMINOTHIAZOLIDIN-4-ONES IN THE SYNTHESIS OF NOVEL DISPIRO-FUSED OXINDOLEPYRROLIDINEIMINOTHIAZOLIDINONES

Authors

  • Алексей Н. Изместьев N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Андрей A. Стрельцов N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991 D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047
  • Ангелина Н. Кравченко N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Галина A. Газиева N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

DOI:

https://doi.org/10.1007/7442

Keywords:

azomethine ylides, iminothiazolidinones, isatins, spirooxindole, antiproliferative activity, 1, 3-dipolar cycloaddition

Abstract

A novel series of dispiro(indolinonepyrrolidineiminothiazolidinones) were synthesized by 1,3-dipolar cycloaddition of 5-arylmethylidene-2-iminothiazolidin-4-ones and azomethine ylides generated from N-alkylamino acids and isatin derivatives. A number of iminothiazolidinones and dispiro compounds were tested for antiproliferative activity. Seven compounds showed moderate antiproliferative activity at micromolar concentrations against cancer cell lines.

Authors: Alexei N. Izmest'ev, Andrey А. Streltsov, Angelina N. Kravchenko, Galina А. Gazieva*

Author Biographies

Алексей Н. Изместьев, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

старший научный сотрудник лаборатории азотсодержащих соединений № 19 ИОХ РАН

Андрей A. Стрельцов, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991 D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow 125047

инженер лаборатории азотсодержащих соединений № 19 ИОХ РАН

Ангелина Н. Кравченко, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

ведущий научный сотрудник лаборатории азотсодержащих соединений № 19 ИОХ РАН

Галина A. Газиева, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991

Russian Academy of sciences

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Published

2023-05-31

Issue

Vol. 59 No. 4/5 (2023)

Section

Original Papers