CYTOTOXICITY OF METAL 8-QUINOLINETHIOLATES

Authors

  • Э. Лукевиц Latvian Institute of Organic Chemistry, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Chemistry, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Chemistry, Riga LV-1006
  • А. Нестерова Latvian Institute of Organic Chemistry, Riga LV-1006
  • Д. Зарума Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169
  • Я. Ашакс Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169

DOI:

https://doi.org/10.1007/7952

Keywords:

8-quinolinethiolates of metals, cytotoxicity

Abstract

High cytotoxicity has been established for the 8-quinolinethiolates of copper, cadmium, indium, antimony, bismuth, ruthenium, rhodium, palladium, osmium, iridium, and platinum on HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma), and B-16 (mouse  melanoma)  tumor cells. The greatest activity  against HT-1080 was possessed by the iridium complex, and against MG-22A by the osmium complex. All the investigated metal 8-quinolinethiolates were highly toxic in relation to NIH 3T3 normal mouse embryo fibroblasts.

How to Cite
Lukevics, E.; Shestakova, I.; Domracheva, I.; Nesterova, A.; Zaruma, D.; Ashaks, J.  Chem. Heterocycl. Compd. 2006, 42, 761. [Khim. Geterotsikl. Soedin. 2006, 870.]

For this article in the English edition see DOI 10.1007/s10593-006-0158-3


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Published

2023-08-14

Issue

No. 6 (2006)

Section

Original Papers