THE SYNTHESIS OF <i>N</i>-SUBSTITUTED 2-AMINO-1,4,5,6-TETRAHYDROPYRIMIDINES FROM ISOCYANATES

Authors

  • Dmitry S. Ivanov Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997
  • Alexander Yu. Smirnov Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997; Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997
  • Mikhail S. Baranov Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997; Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997

Keywords:

2-amino-1,4,5,6-tetrahydropyrimidines, tert-butoxycarbonyl protection of guanidines, cyclic guanidines

Abstract

A simple procedure for the synthesis of N-substituted 2-amino-1,4,5,6-tetrahydropyrimidines from isocyanates with a wide variety of substituents was developed.

Author Biographies

Dmitry S. Ivanov, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997

Группа химии гетероциклических соединений

Alexander Yu. Smirnov, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997; Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997

Группа химии гетероциклических соединений

Mikhail S. Baranov, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997; Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow 117997

Группа химии гетероциклических соединений

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Published

2024-01-10

Issue

Vol. 59 No. 11/12 (2023)

Section

Short Communications