SYNTHESIS OF NEW 1H-1,2,4-TRIAZOLYLCOUMARINS AND THEIR ANTITUMOR AND ANTI-HIV ACTIVITIES

Authors

  • Y. A. Al-Soud Department of Chemistry,College of Science, University of Al al-Bayt, Al-Mafraq
  • I. A. Al-Masoud College of Veretinary, University of Basrah, Basrah
  • B. Saeed Department of Chemistry, College of Education, University of Basrah, Basrah
  • U. Beifuß Fakultät für Chemie, Universität Hohenheim
  • N. A. Al-Masoudi Formerly Fachbereich Chemie, Universität Konstanz

DOI:

https://doi.org/10.1007/7969

Keywords:

antitumor activity, antiviral activity, coumarin, 1, 2, 4-triazoles, cycloaddition

Abstract

A variety of 7-[(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins were synthe-

sized from cycloaddition of 2-(2H-benzopyran-7-yloxy)acetonitrile and 2-(5-methoxy-4-methyl-
2H-benzopyran-7-yloxy)acetonitrile, respectively, with various reactive  C=N=N+
cumulene intermediates via spontaneous rearrangements.  
Anticancer  (breast,  lung,  CNS cancers) and antiviral (HIV-1, HIV-2) properties of some compounds were investigated  in vitro. 5-Methoxy-4-methyl-7-[(6,7,8,9-tetrahydro-5H-[1,2,4]-triazolo[1,5-a]azepin-2-yl)methyl]coumarin showed some inhibition of HIV-1.

How to Cite
Al-Soud, Y. A.; Al-Masoudi, I. A.; Saeed, B.; Beifuß, U.; Al-Masoudi, N. A. Chem. Heterocycl. Compd. 2006, 42, 583. [Khim. Geterotsikl. Soedin. 2006, 669.]

For this article in the English edition, see DOI 10.1007/s10593-006-0130-2

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Published

2023-08-17

Issue

No. 5 (2006)

Section

Original Papers