SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF NEW BENZIMIDAZOLE DERIVATIVES

Authors

  • H. Foks Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk
  • D. Pancechowska-Ksepko Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk
  • W. Kuźmierkiewicz Department of Organic Chemistry, Medical University of Gdańsk, 80-416 Gdańsk
  • Z. Zwolska Department of Microbiology, Institute of Tuberculosis and Pulmonary, Diseases 01-138 Warszawa
  • E. Augustynowicz-Kopeć Department of Microbiology, Institute of Tuberculosis and Pulmonary, Diseases 01-138 Warszawa
  • M. Janowiec Department of Microbiology, Institute of Tuberculosis and Pulmonary, Diseases 01-138 Warszawa

DOI:

https://doi.org/10.1007/7974

Keywords:

benzimidazoles, methane- and benzenesulfonamides, tuberculostatics

Abstract

The reactions of  o-phenylenediamine and 3,4-diaminotoluene with such acids as 3-cyclo-
hexylpropionic, 4-phenylbutyric, 4-cyclohexylbutyric, 3,3-diphenylpropionic and 3,4-dimethoxy-
phenylacetic resulted in the formation of corresponding  2-substituted benzimidazoles. These compounds were transformed into  methane-  and benzenesulfonamide derivatives. The benz-
imidazole derivatives obtained  were  tested  in vitro towards their tuberculostatic activity. Compounds with good activity (MIC 6.2–25 µg/ml) have been found.

How to Cite
Foks, H.; Pancechowska-Ksepko, D.; Kuźmierkiewicz, W.; Zwolska, Z.;  Augustynowicz-Kopeć, E.; Janowiec, M.  Chem. Heterocycl. Compd. 2006, 42, 611. [Khim. Geterotsikl. Soedin. 2006, 697.]

For this article in the English edition, see DOI 10.1007/s10593-006-0135-x

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Published

2023-08-17

Issue

No. 5 (2006)

Section

Original Papers