A NOVEL FACILE APPROACH TO OBTAIN PHENYTOIN AND THIOPHENYTOIN USING NEW DEEP EUTECTIC SOLVENT-LIKE MIXTURES OF UREA, THIOUREA, AND KOH

Authors

  • Елена В. Ховренко
  • Вадим Ю. Баула
  • Виктория В. Штрыкова
  • Вера Ю. Куксёнок
  • Виктор Д. Филимонов

Keywords:

benzil, deep eutectic solvents, hydantoins, thioureas, ureas

Abstract

Urea and thiourea formed relatively stable liquid deep eutectic mixtures with KOH at certain ratios. These mixtures showed high activity in the reaction with benzils, quickly forming hydantoins and thiohydantoins in high yields.

 

Author Biographies

Елена В. Ховренко

Tomsk Polytechnic University,
Kizhner Research Center,
43а Lenina Ave., Tomsk 634050, Russia

Вадим Ю. Баула

Tomsk Polytechnic University,
Kizhner Research Center,
43а Lenina Ave., Tomsk 634050, Russia

Виктория В. Штрыкова

Tomsk Polytechnic University,
Kizhner Research Center,
43а Lenina Ave., Tomsk 634050, Russia

Вера Ю. Куксёнок

Tomsk Polytechnic University,
Kizhner Research Center,
43а Lenina Ave., Tomsk 634050, Russia

Виктор Д. Филимонов

Tomsk Polytechnic University,
Kizhner Research Center,
43а Lenina Ave., Tomsk 634050, Russia

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Published

2024-03-26

Issue

Vol. 60 No. 1/2 (2024)

Section

Short Communications