4-HYDROXY-2-QUINOLONES. 92. REACTION OF 1-R-4-CHLORO-3-ETHOXYCARBONYL-2-OXO-1,2- DIHYDROQUINOLINES WITH ANILINES

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkov 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkov 61002
  • О. В. Горохова National Pharmaceutical University, Kharkov 61002
  • Н. А. Джарадат An-Najah National University College of Pharmacy, P.O. Box 7, Nablus

DOI:

https://doi.org/10.1007/8025

Keywords:

4-ариламино-2-оксо-1, 2-дигидрохинолины, декарбоксилирование, противовоспалительная активность, РСА

Abstract

A preparative method is proposed and the synthesis  of 4-arylamino-2-oxo-1,2-dihydroquinolines has been effected. An X-ray structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried out enabling the ease of decarboxylating such compounds to be substantiated. Results are given  of a study of the anti-inflammatory activity of the synthesized compounds.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Jaradat, N. A.  Chem. Heterocycl. Compd. 2006, 42, 343. [Khim. Geterotsikl. Soedin. 2006, 386.]

For this article in the English edition, see DOI 10.1007/s10593-006-0091-5


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Published

2023-09-04

Issue

No. 3 (2006)

Section

Original Papers