SYNTHESIS OF COMPLEX COMPOUNDS OF METHYL DERIVATIVES OF 8-QUINOLINESELENOL WITH METALS AND THEIR CYTOTOXIC ACTIVITY

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Нестерова Latvian Institute of Organic Synthesis, Riga LV-1006
  • Я. Ашакс Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169
  • Д. Зарума Institute of Inorganic Chemistry, Riga Technical University, Salaspils LV-2169

DOI:

https://doi.org/10.1007/8081

Keywords:

metal methyl-8-quinolineselenolates, cytotoxicity

Abstract

A series of 2-methyl-, 4-methyl-, and 2,4-dimethyl-8-quinolineselenolates of zinc, cadmium, mercury, nickel, palladium, platinum, arsenic, antimony, and bismuth has been synthesized and their cytotoxicity has been studied on HT-1080 (human fibrosarcoma), MG-22A (mouse hepatoma), B16 (mouse melanoma), and Neuro 2A (mouse neuroblastoma) tumor cells. Mercury complexes were distinguished by high cytotoxicity on all the cell lines. Palladium complexes possessed somewhat lower activity and were significantly less toxic in relation to normal NIH 3T3 mouse embryo fibroblasts. All the studied metal 2-methyl-8-quinolineselenolates displayed high cytotoxicity on B16 melanoma, arsenic 4-methyl-8-quinolineselenolate acted most effectively on  HT-1080 and MG-22A cells. Di(4-methyl-8-quinolyl) diselenide also possessed high cytotoxicity on these same cells.

How to Cite
Lukevics, E.; Shestakova, I.; Domracheva, I.; Nesterova, A.; Ashaks, J.; Zaruma, D.  Chem. Heterocycl. Compd. 2006, 42, 53. [Khim. Geterotsikl. Soedin. 2006, 59.]

For this article in the English edition, see DOI 10.1007/s10593-006-0046-x


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Published

2023-09-20

Issue

No. 1 (2006)

Section

Original Papers