TECHNOLOGY OF PREPARING 8-HYDROXY-5-NITROQUINOLINE

Authors

  • А. А. Исаев Institute of the Chemistry of Plant Substances, Academy of Sciences of Republic Uzbekistan, 700170
  • О. И. Ломовский Institute of Chemistry of Solid State and of Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630128
  • К. Г. Королев Institute of Chemistry of Solid State and of Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630128
  • Р. К. Каримов Institute of the Chemistry of Plant Substances, Academy of Sciences of Republic Uzbekistan, 700170

DOI:

https://doi.org/10.1007/8222

Keywords:

8-hydroxy-5, 7-dinitroquinoline, 8-hydroxy-5-nitrosoquinoline, 8-hydroxy-5-nitroquinoline, 8-hydroxy-7-nitroquinoline, 8-hydroxyquinoline, nitration, nitrosation, oxidation, purification

Abstract

An efficient, two stage method is proposed for the  preparation of 8-hydroxy-5-nitroquinoline based on the nitrosation of 8-hydroxyquinoline and subsequent oxidation of the nitroso derivative using nitric acid. The conditions for the nitrosation and oxidation of the 8-hydroxyquinoline (concentration of nitric acid, temperature, and reaction time) were optimized. A method for purifying the target compound is presented.

How to Cite
Isaev, A. A.; Lomovskii, I. I.; Korolev, K. G.; Karimov, R. K.  Chem. Heterocycl. Compd. 2005, 41, 1027. [Khim. Geterotsikl. Soedin. 2005, 1204.]

For this article in the English edition, see DOI 10.1007/s10593-005-0273-6


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Published

2023-10-30

Issue

No. 8 (2005)

Section

Original Papers