SILYL MODIFICATION OF BIOLOGICALLY ACTIVE COMPOUNDS. 10. LIPID TYPE ORGANOSILICON DERIVATIVES OF 8-HYDROXYQUINOLINE AND N-(2-HYDROXYETHYL)-1,2,3,4-TETRAHYDRO(SILA, ISO)QUINOLINES

Authors

  • И. Сегал Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Заблоцкая Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/8300

Keywords:

tetrahydroisoquinoline, tetrahydroquinoline, alkylation, phase-transfer catalysis, psychotropic activity, silylation

Abstract

Organosilicon alkylation of the primary alcoholic  groups of N-(2-hydroxyalkyl) derivatives of 1,2,3,4-tetrahydroquinoline, tetrahydroisoquinoline, and 4,4-dimethyltetrahydro-4-silaisoquinoline, and also the hydroxyl group of 8-hydroxyquinoline by trialkyl-chloroalkylsilanes under conditions of phase-transfer catalysis has been investigated. The neurotropic properties and acute toxicity of the synthesized compounds have been investigated.

How to Cite
Segal, I.; Zablotskaya, A.; Lukevics, E.  Chem. Heterocycl. Compd. 2005, 41, 613. [Khim. Geterotsikl. Soedin. 2005, 713.]

For this article in the English edition, see DOI 10.1007/s10593-005-0192-6


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Published

2023-11-14

Issue

No. 5 (2005)

Section

Original Papers