SCHIZOCOMMUNIN-INSPIRED HETEROCYCLIC HYBRID MOLECULES

Authors

  • Bhawna Chechani Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001
  • Mukesh Kumar Sahu Jain College, Najibabad, Bijnor, affiliated to M. J. P. Rohilkhand University, Bareilly
  • Dinesh K. Yadav Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001
  • Siddharth Sharma Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001
  • Neetu Kumari Department of Chemistry, Mohanlal Sukhadia University, Udaipur-313001

Keywords:

Schizocommunin, Anticancer activity, Quinazolinones, Click reaction.

Abstract

An effective and environmentally friendly technique for synthesizing hybrid molecules based on schizocommunin has been detailed in this study. This process involves a click reaction utilizing quinazolinones, isatin, and azides. Schizocommunin, a natural bioactive compound recognized for its wide array of biological functions including its anticancer properties, was employed as the foundational scaffold. The resultant triazo compounds originating from schizocommunin were subjected to thorough evaluation for their potential anticancer activity against three human cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), and PC-3 (prostate cancer), through employment of the MTT assay. One compound from the series showcased a remarkable anticancer efficacy (IC50 2.35 ± 0.67 μM) against MCF-7.

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Published

2024-08-01

Issue

Vol. 60 No. 5/6 (2024)

Section

Original Papers