ELECTROCHEMICAL OXIDATION OF COMPOUNDS CONTAINING 1,4-DIHYDROPYRIDINE AND PYRIDINIUM RINGS – ANALOGS OF GENE TRANSFECTION AGENTS

Authors

  • B. Turovska Latvian Institute of Organic Synthesis, Riga LV 1006
  • J. Stradins Latvian Institute of Organic Synthesis, Riga LV 1006
  • I. Turovskis Latvian Institute of Organic Synthesis, Riga LV 1006
  • A. Plotniece Latvian Institute of Organic Synthesis, Riga LV 1006
  • A. Shmidlers Latvian Institute of Organic Synthesis, Riga LV 1006
  • G. Duburs Latvian Institute of Organic Synthesis, Riga LV 1006

Keywords:

dihydropyridine anions, dipyridines, 1,4-dihydropyridines, oxidation mechanis, electrochemical oxidation

Abstract

A study was carried out on the electrochemical oxidation of 1,4-dihydropyridines, found as substituents in pyridinium salts, which are strong electron acceptors. The potentials for their oxidation in acetonitrile were determined. NMR spectroscopy was used to find the relative acidity of the N–H and C–H protons and the oxidation potentials were determined for the anionic products of the ionization of the N–H bond in dihydropyridine. The only product of the preparative electrolysis, in contrast to chemical oxidation, is the corresponding pyridine, namely, the oxidized dihydropyridine form.

How to Cite
Turovska, B.; Stradins, J.; Turovskis, I.; Plotniece, A.; Shmidlers, A.; Duburs, G. Chem. Heterocycl. Compd. 2004, 40, 753. [Khim. Geterotsikl. Soedin. 2004, 880.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000040771.98660.f0

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Published

2004-06-25

Issue

No. 6 (2004)

Section

Original Papers