ACTIVATION OF PYRIDINIUM SALTS FOR ELECTROPHILIC ACYLATION: A METHOD FOR CONVERSION OF PYRIDINES INTO 3-ACYLPYRIDINES

Authors

  • A. Klapars Department of Process Research, Merck Research Laboratories, NJ 07065
  • E. Vedejs Department of Chemistry, University of Michigan, Ann Arbor, MI 48109

Keywords:

dihydropyridines, pyridine acylation

Abstract

Cyanide adducts of N-MOM pyridinium salts react with strong acylating reagents to provide 3-acyl-4-cyano-1,4-dihydropyridines that can be aromatized to 3-acylpyridines using ZnCl2 in refluxing ethanol.

How to Cite
Klapars, A.; Vedejs, E. Chem. Heterocycl. Compd. 2004, 40, 759. [Khim. Geterotsikl. Soedin. 2004, 887.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000040772.13427.0b

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Published

2004-06-25

Issue

No. 6 (2004)

Section

Original Papers