SYNTHESIS OF DERIVATIVES OF 8-CYANO-6-ETHOXYCARBONYL-3-HYDROXY-5-METHYLIMIDAZO[1,2-a]PYRIDINE AND 9-ALKOXYCARBONYL- (OR 9-CARBOXY)-3-ETHOXYCARBONYL-2-METHYL-10H-BENZO[b]-1,8-NAPHTHYRIDINE-5-ONE FROM THE REACTION OF 2-CHLORO-5-ETHOXYCARBONYL-6-M

Abstract

2-Substituted 8-cyano-6-ethoxycarbonyl-3-hydroxy-5-methylimidazo[1,2-a]pyridine was formed from the interaction of 2-chloro-5-ethoxycarbonyl-6-methylnicotinonitrile with α-amino acids in DMF. The same nitrile on boiling with anthranilic acid or its esters in butanol gave, respectively, 2-(2-carboxyanilino)- or (2-(2-alkoxycarbonylanilino)-5-ethoxycarbonyl-6-methylnicotinonitriles which cyclized on heating in PPA to give 9-alkoxycarbonyl(or 9-carboxy)-3-ethoxycarbonyl-2-methyl-10H-benzo[b]-1,8-naphthyridin-5-ones.

How to Cite
Deyanov, A. B.; Konshin, M. E. Chem. Heterocycl. Compd. 2004, 40, 510. [Khim. Geterotsikl. Soedin. 2004, 608.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000033548.10379.02