SYNTHESIS AND HETEROCYCLIZATION OF β-AROYL-α-DIPHENYLPHOSPHORYLPROPIONIC ACIDS

Authors

  • Р. А. Хачатрян Institute of Organic Chemistry, National Academy of Sciences (NAN) of Armenia, Erevan 375091
  • Р. Дж. Хачикян Institute of Organic Chemistry, National Academy of Sciences (NAN) of Armenia, Erevan 375091
  • Н. В. Карамян IInstitute of Organic Chemistry, National Academy of Sciences (NAN) of Armenia, Erevan 375091
  • Г. А. Паносян Institute of Organic Chemistry, National Academy of Sciences (NAN) of Armenia, Erevan 375091
  • М. Г. Инджикян Institute of Organic Chemistry, National Academy of Sciences (NAN) of Armenia, Erevan 375091

Keywords:

β-aroylacrylic acids, dihydropyridazinones, diphenylphosphine oxide, diphenylphosphoryldihydrooxazinones, diphenylphosphoryltetrahydropyridazinones, imidazole, pyrazolinecarboxylic acids

Abstract

It has been established that diphenylphosphine oxide reacts smoothly with β-aroylacrylic acids with the formation of β-aroyl-α-diphenylphosphorylpropionic acids, which were cyclized under the action of hydroxylamine, hydrazine hydrate, and phenylhydrazine hydrochloride into phospho derivatives of dihydrooxazinone and tetrahydropyridazinone respectively. It was shown that imidazole may serve as nucleophilic protection for the synthesis of dihydropyridazinone derivatives from β-aroylacrylic acids.

How to Cite
Khachatryan, R. A.; Khachikyan, R. J.; Karamyan, N. V.; Panosyan, G. A.; Indzhikyan, M. G. Chem. Heterocycl. Compd. 2004, 40, 446. [Khim. Geterotsikl. Soedin. 2004, 541.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000033535.93962.f5

Downloads

Published

2004-04-25

Issue

No. 4 (2004)

Section

Original Papers