SYNTHESIS OF 2-TRIHALOMETHYL-3,4-DIHYDROTHIENO[2,3-<i>d</i>]PYRIMIDIN-4-ONES

Authors

  • М. В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • А. В. Больбут Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • В. И. Бойко Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • В. В. Пироженко Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • А. Н. Чернега Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • А. А. Толмачев Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094

Keywords:

2-aminothiophenes, N-(2-thienyl)-N'-methoxycarbonylamidines, 2-trihalomethyl-3,4-dihydrothieno[2,3-d]pyrimidin-4-ones, N-(1-chloro-2,2,2-trihaloethylidene)-O-methyl urethanes, intramolecular cyclization

Abstract

At room temperature, N-(1-chloro-2,2,2-trihaloethylidene)-O-methyl urethanes react with 2-aminothiophenes to form N-(2-thienyl)-N'-(methoxycarbonyl)trihaloacetamidines, which when heated in boiling toluene undergo ring closure to form 2-trihalomethyl-3,4-dihydrothieno[2,3-d]pyrimidin-4-ones.

How to Cite
Vovk, M. V.; Bolbut, A. V.; Boiko, V. I.; Pirozhenko, V. V.; Chernega, A. N.; Tolmachev, A. A. Chem. Heterocycl. Compd. 2004, 40, 370. [Khim. Geterotsikl. Soedin. 2004, 455.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000028635.82517.f2

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Published

2004-03-25

Issue

No. 3 (2004)

Section

Original Papers