SYNTHESIS AND REACTIONS OF POLYHEDRAL COMPOUNDS. 27. DEVELOPMENT OF A SYNTHETIC ROUTE FOR 2- SPIRO-SUBSTITUTED 6-HYDROXY-5,7-DIMETHYL-1,3-DIAZAADAMANTANES

Authors

  • Ц. Е. Агаджанян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Armenian Republic
  • Г. Л. Арутюнян A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Armenian Republic
  • Р. К. Шахатуни A. L. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of the Armenian Republic

Keywords:

3,7-diazabicyclo[3.3.1]nonane, spiro-1,3-diazaadamantane, cyclic ketones, reduction, condensation

Abstract

Alternative methods for the synthesis of 2-spiro-substituted 6-hydroxy-5,7-dimethyl-1,3-diazaadamantanes have been developed. These are the reduction of the ketone group to hydroxyl in the corresponding 6-oxo-1,3-diazaadamantanes and the condensation of 9-hydroxy-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonane (obtained by different routes from 5,7-dimethyl-6-oxo-1,3-diazaadamantane) in reaction with cyclic ketones.

How to Cite
Aghajanian, Ts. Ye.; Arutyunian, G. L; Shahkhatuni, R. K. Chem. Heterocycl. Compd. 2003, 39, 767. [Khim. Geterotsikl. Soedin. 2003, 895.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1025699129643

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Published

2003-06-25

Issue

No. 6 (2003)

Section

Original Papers