SYNTHESIS OF STEROIDS WITH NITROGEN-CONTAINING SUBSTITUENTS IN RING D

Abstract

Data published over the last 15 years on the chemical synthesis of biologically active steroids with nitrogen-containing substituents (mostly containing nitrogen heterocycles) in ring D are reviewed. Modern methods for the synthesis of nitrogen-containing derivatives from 17-keto steroids and 20-keto steroids and certain other methods for the synthesis of the target products are discussed. Concise data are also presented on three of the most important biological targets for nitrogen-containing steroids: enzymes 17α‑hydroxylase-17/20-lyase (CYP17), aromatase (CYP19), and 24-sterol methyltransferase (SMT).

Authors: S. V. Stulov and A. Yu. Misharin

English Translation in Chemistry of Heterocyclic Compounds, 2013, 48 (10), pp 1431-1472

http://link.springer.com/article/10.1007/s10593-013-1158-8