2-CHLORO-3-QUINOLINECARBOXALDEHYDE IN THE SYNTHESIS OF CONDENSED QUINOLINE SYSTEMS. 1. SYNTHESIS OF DERIVATIVES OF 3,4-DIHYDRO-2H-[1,3]THIAZINO[6,5-<i>b</i>]QUINOLINES
Keywords:
3,4-dihydro-2H-[1,3]thiazino[6,5-b]quinolines, 2-methoxyethylamine, Schiff's base, thiourea, intramolecular nucleophilic cyclizationAbstract
A method for the synthesis of derivatives of previously unknown heterocyclic systems – 3,4-dihydro-2H-[1,3]thiazino[6,5-b]quinolines – has been developed based on 7,8-dimethyl-2-chloro-3-quinolinecarboxaldehyde via the consecutive steps of conversion into its Schiff's base with a primary amine, reduction to the corresponding aminomethyl derivative, conversion to the thiourea with isothiocyanates, and heterocyclization by intramolecular substitution of the chlorine atom.
How to Cite
Kombarov, P. V.; Yurovskaya, M. A. Chem. Heterocycl. Compd. 2003, 39, 364. [Khim. Geterotsikl. Soedin. 2003, 410.]
For this article in the English edition, see DOI https://doi.org/10.1023/A:1023975129116
