SYNTHESIS OF NEW FLUORINATED DERIVATIVES OF QUINOLINECARBOXYLIC ACIDS

Authors

  • Э. B. Носова Urals State Technical University, Ekaterinburg 620002
  • Л. П. Сидорова Urals State Technical University, Ekaterinburg 620002
  • Г. Н. Липунова Urals State Technical University, Ekaterinburg 620002
  • H. Н. Мочульская Urals State Technical University, Ekaterinburg 620002
  • O. M. Часовских Urals State Technical University, Ekaterinburg 620002
  • B. Н. Чарушин Urals State Technical University, Ekaterinburg 620002

Keywords:

quinolone-3-carboxylic acid hydrazides, 1,3,4-oxadiazino[6,5,4-i,j]quinolines, reactivity, spectral characteristics

Abstract

Ethyl esters of 1-(7-Z-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbamoyl)-5-X-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids (X = H, F; Z = pyrrolidino-, piperidino-, hexamethylenimino-, morpholino-, thiomorpholino-) have been synthesized by the interaction of quinolone-3-carboxylic acid hydrazides with ethyl esters of 3-ethoxy-2-(polyfluorobenzoyl)acrylic acid. It was shown possible to cyclize intramolecularly the esters obtained with the formation of 1,3,4-oxadiazino[6,5,4-i,j]quinoline derivatives.

How to Cite
Nosova, E. V.; Sidorova, L. P.; Lipunova,  G. N.; Mochul'skaya, N. N.; Chasovskikh, O. M.; Charushin, V. N. Chem. Heterocycl. Compd. 2002, 38, 922. [Khim. Geterotsikl. Soedin. 2002, 1060.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020965312463

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Published

2002-08-25

Issue

No. 8 (2002)

Section

Original Papers